Unstoppable (2010)

Genre: Action | Drama | Thriller
Stars: Denzel Washington, Chris Pine and Rosario Dawson
Plot: With an unmanned, half-mile-long freight train barreling toward a city, a veteran engineer and a young conductor race against the clock to prevent a catastrophe.

http://www.imdb.com/title/tt0477080/
http://en.wikipedia.org/wiki/Unstoppable_(2010_film)