Bubble Boy (2001)

Cast : Jake Gyllenhaal, Swoosie Kurtz, Marley Shelton, Danny Trejo, John Carroll Lynch, Verne Troyer, Dave Sheridan, Brian George, Patrick Cranshaw, Stephen Spinella, Ever Carradine, Geoffrey Arend, Beetlejuice, Matthew McGrory, Bonnie Morgan

Story Summary :
"Bubble Boy" is a comedy about a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom. When he finds out that the woman he has loved since childhood is about to be married at Niagara Falls, he builds a portable bubble suit and ventures into the outside world to win her affections.

See:
# Bubble Boy at Wikipedia